Block a registry key to prevent rewriting or deleted accidentally or intentionally by command line

I see the post in superuser and i have a similar case, but with a small difference.

I created a reg key.

"HKLMSOFTWAREMicrosoftWindows NTCurrentVersionImage File Execution Optionswscript.exe"

And the content target: /windows/system32/wscript.exe

And I need to block this key permanently (or any other key that I want to create), to prevent accidental or intentional deletion or modification of any malware

Question:

What command line can help me to do this? (cmd or powershell or both)

Thanks

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