MSI LaunchCondition fails for .Net Framework 4.5.1

Currently I have the problem, that ruing a setup fails at executing / proofing the LaunchCondition for .Net Framework 4.5.1. But the .net framework is installed correctly and other applications are ruing correctly too. The problems is occuring on a Windows Server 2012 R2. I've already tried the .net repair-tool, but nothing seems to help: .Net Repair tool

Also this articles does not help too but contains some important information:

1. https://blogs.msdn.microsoft.com/astebner/2008/08/28/net-framework-cleanup-tool-users-guide/
2. https://blogs.msdn.microsoft.com/astebner/2006/07/20/repairing-the-windows-installer-service-on-a-64-bit-os/

Has anyone solved this problem before?