difference in two strings by substring search

Do you think it is possible with notepad++ to do difference of two strings on a substring level??

Check if any element from list1 exists in list2. If so remove it. At the end retu only those unique

list1    - "a" "b" "a" "a" "c" "f" "g"
list2    - "a" "c" "a" "f"
-------------------
result   - "b" "g"

list1 and list2 could be two separate files or just two separate lines. Elements could be comma separated or just whitespace/spacebar separated

Would be cool to know. Thanks in advance!

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