Keyboard and Mouse not working after wake up; independent of OS

When I did a full reinstall of Windows and Linux Mint, I changed all the settings of the mainboard to boot in UEFI and tued off all compatibility settings like xHCI hand-off and so on.

I was at first very happy with these settings because the computer would boot faster and finally sleep would also work with Linux Mint on my system.

I can use the keyboard or mouse to wake up the machine, but after that both are not working anymore, meaning I have to press the reset button and restart the computer.

It behaves the same on Windows 10 and Linux.

I suspect another weird thing might have something to do with my issue. From the first day I had my PC (in BIOS mode), if the PC was completely tued off, my mouse and keyboard wouldn't work in the OS. They would work fine in the bios. I again have to press the reset button and after the 2nd boot it would work just fine.

I suspect the mainboard to have either an issue or a bad setting. But what could it be?

Help is very appreciated!

Thank you!

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