USB flash drive ruing Windows 10?

I want to run Win10 from a USB flash drive but I want it to run fast. I found a specific product and it can r/w sequentiallly 245/190 MBps which is more than some SSDs are capable of. Although I don't have information about the non-sequential performance which is critical for system disks as far as I know.

I know that Linux is capable of ruing quickly on almost any kind of drive but Windows is very very sensitive to drive performance and becomes unusably slow on a regular performance drive.

Is such a fast pendrive a good choice for a system disk? I want Windows to run faster than on an HDD would and almost as fast as a built-in SSD would be.