Visual Studio 2015 Application properties window null reference error

When I click on the properties of a solution the visual studio writes me:

An error occurred trying to load the page.
Property accessor 'TargetDescriptions' on object 'Microsoft.VisualStudio.ProjectFlavoring.Automation.Project.CommonProjectExtender' threw the following exception:'Value caot be null.
Parameter name: targets'

I don't get what does it means. A few day ago it worked and I didn't modified anything that could do this error.

I installed only nuget package manager and Codemaid, but I use them long time ago.

null reference error screenshot:

What can make problems like this in visual studio 2015 update 2? Should I downgrade?