Hidden Files : Odd large system files taking up space on hard drive

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in the above image there are 4 sys files that I have no idea where they came from. Is anyone familiar with these? Do I have a virus?

they are attributed as HSA. i have been able to see all hidden files and I have been able to locate these files. upon trying to delete I have run a cmd to take ownership and rebooted to Safe Mode. tried deleting the four files and it says that the "files are in use by another program". Under processes and services I do not know what to stop to be able to delete these files? Can I delete these? If so, how?